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Ibuprofen 400mg offers a balance of powerful pain relief with a low risk of GI side effects.^1-4 GI adverse effects are one of the main concerns associated with the use of non-selective NSAIDs and are dependent on the dose and duration of exposure.5 It’s important to consider as GI tolerability is important to patients as are speed of onset and duration of action of OTC NSAIDs.5 Pain relief you expect from an NSAID4 GI tolerability you expect from paracetamol1-3^ SAME LOW RISK of GI side-effects as paracetamol1-3^ 4% IBUPROFEN vs 5.3% PARACETAMOL1 GI events (including dyspepsia) Ibuprofen 400mg Naproxen 440mg Paracetamol 975/ 1000mg 45% 34% Percentage of patients with at least 50% pain relief 43% STEP UP to ibuprofen 200mg/paracetamol 500mg for powerful dual action pain relief in one tablet that’s well tolerated.^4,6 Ibuprofen 200mg/ paracetamol 500mg Ibuprofen 400mg Naproxen 440mg Paracetamol 975/1000mg 67% Tolerability you expect from the single actives6^ 6.3% IBUPROFEN 200MG/ PARACETAMOL 500MG vs 10.8% IBUPROFEN 400MG vs 13.5% PARACETAMOL 1000MG Total treatment-related adverse events between first and second doses Percentage of patients with at least 50% pain relief 34% 45% 43% ^When taken as directed in an over-the-counter setting in people without contraindications/precautions. GI: gastrointestinal. NSAID: non-steroidal anti-inflammatory drug. OTC: over-the-counter. Nurofen 400 Double Strength contains 400mg ibuprofen. For the temporary relief of pain. References: 1. Moore RA et al. Clin Drug Invest 1999;18(2):89-98. 2. Rampal P et al. J Int Med Res 2002;30:301–308. 3. Varrassi G et al. Adv Ther 2019; doi: 10.1007/s12325-019-01144-9. 4. Moore RA, et al. Cochrane Datab Syst Rev 2015;11:CD010794. 5. Bjarnason I, et al. J Pharm Pharmacol 2017;70(2):223-233. 6. Mehlisch DR, et al. Clin Ther 2010;32(6):1033-1049. ®NUROFEN is a registered trademark of the Reckitt Benckiser Group of Companies. Level 47, 680 George St, Sydney 2000, NSW Australia. Prepared December 2020.