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For the two sides of osteoarthritis pain Panadol Osteo For everyday osteoarthritis pain... • For persistent pain – a modified release paracetamol for pain relief for up to 8 hours1,2 • Bi-layer formulation provides immediate and sustained release of paracetamol1 • 3x daily dosing GI = gastro-intestinal; NSAID = non-steroidal anti-inflammatory drugs; OA = osteoarthritis. Voltaren Osteo Gel 12 Hourly for flare-up days • Contains topical diclofenac to relieve pain and reduce inflammation for up to 12 hours3 • Concentrates at the site of application4 • The incidence of local adverse events is increased with topical NSAIDs, but gastrointestinal adverse events are reduced compared with oral NSAIDs5 Panadol Osteo contains Paracetamol 665 mg per caplet. Pharmacy-Only Medicine. Indications and dosage: For temporary relief of persistent pain of osteoarthritis. Adults and children ≥ 12 years: 2 caplets every 6–8 hours. Contraindications: Patients with a previous history of hypersensitivity to paracetamol or to any of the excipients; in children under 12 years. Precautions: Equally space dosage within a day. Do not take with allergy to paracetamol, seek medical advice with liver or kidney disease. Adverse reactions (very rare): Thrombocytopenia; anaphylaxis, cutaneous hypersensitivity reactions including skin rashes, angioedema and Stevens Johnson syndrome; bronchospasm, especially in patients sensitive to aspirin and other NSAIDs; hepatic dysfunction. Voltaren Osteo Gel 12 Hourly contains diclofenac diethylamine 23.2 mg/g. Indications and dosage: For short-term (up to 3 weeks) pain relief of mild and localised forms of osteoarthritis of the knees and fingers. Adults and children ≥ 12 years: Apply to affected area up to 2 times a day. Contraindications: Hypersensitivity to any ingredient; in asthma attacks, urticaria or rhinitis precipitated by aspirin or other NSAIDs; in pregnancy or breastfeeding; in children under 12 years. Adverse reactions (common): Rash, eczema, erythema, dermatitis, pruritus. For further information, please contact GlaxoSmithKline Consumer Healthcare (FREECALL 1800 028 533). References: 1. Panadol Osteo (paracetamol). Australian approved Product Information. Ermington: GSK Consumer Healthcare. Approved August 2018. 2. Bacon TH et al. Australian Pain Society 2001;63–4, Abstract E2 (GSK sponsored). 3. Voltaren Osteo Gel 12 Hourly. Patient Information Leaflet. 4. Zacher J et al. Curr Med Res Opin 2008;24:925–50. 5. Derry S, Conaghan PG, Da Silva J et al. Cochrane Database Syst Rev 2016; Iss 4: Art no. CD007400. GlaxoSmithKline Consumer Healthcare. Trademarks are owned by or licensed to the GSK group of companies. ©2019 GSK group of companies or its licensor. GlaxoSmithKlineConsumer Healthcare, 82 Hughes Avenue, Ermington NSW 2115. CHANZ/CHPAN/0032/19B. GLCOCH1007. 05/2019.